203297-M

Bisindolylmaleimide IV

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM).

• Synonym(e): Bisindolylmaleimide IV, Arcyriarubin A, 2,3- bis(1H-Indol-3-yl)maleimide, Ro 31-6233
• Empirische Formel (Hill-System): C₂₀H₁₃N₃O₂
• CAS-Nummer: 119139-23-0
• Molekulargewicht: 327.34
• MDL-Nummer: MFCD00236432
• UNSPSC-Code: 12352111

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (TLC)
• Form: powder; solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze
• Farbe: dark orange
• Löslichkeit: methanol: 10 mg/mL
• Lagertemp.: 2-8°C
• InChI: 1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
• InChIKey: DQYBRTASHMYDJG-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable potent and selective inhibitor of protein kinase C (IC₅₀ = 87 nM) and protein kinase A (IC₅₀ = 2.7 µM).

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM). Inhibits protein kinase A at much higher concentrations (IC₅₀ = 2.7 µM).

Biochem./physiol. Wirkung

Primary Target
PKC

Target IC₅₀: 87 nM against protein kinase C

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sonstige Hinweise

Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable