930547

Pomalidomide-PEG₁-C₂-azide

≥95.0%

• Synonym(e): 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• Empirische Formel (Hill-System): C₁₇H₁₈N₆O₅
• CAS-Nummer: 2271036-44-1
• Molekulargewicht: 386.36
• UNSPSC-Code: 12352125
• NACRES: NA.21

Eigenschaften

• ligand: pomalidomide
• Qualitätsniveau: 100
• Assay: ≥95.0%
• Form: powder
• Funktionelle Gruppe: azide
• Lagertemp.: 2-8°C
• SMILES String: [N-]=[N+]=NCCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3

Beschreibung

Anwendung

Pomalidomide-PEG₁-C₂-azide is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Contains an alkyne, allowing for conjugation through click chemistry. A basic building block for development of a protein degrader library.

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Sonstige Hinweise

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable