930512

VH 032 amide-PEG₃-acid

≥95.0%

• Synonym(e): (S, R, S)-AHPC-PEG₃-acid, 3-Dimethyl-1-oxobutan-2-yl]carbamoyl}ethoxy)ethoxy]ethoxy}propanoic acid, 3-{2 -[2-(2-{[(2S)-1-[(2S,4R)-4-Hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3, N-[3-[2-[2-(2-Carboxyethoxy)ethoxy]ethoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, L-Prolinamide
• Empirische Formel (Hill-System): C₃₂H₄₆N₄O₉S
• CAS-Nummer: 2140807-42-5
• Molekulargewicht: 662.79
• MDL-Nummer: MFCD32693314
• UNSPSC-Code: 12352106

Eigenschaften

• ligand: VH032
• Qualitätsniveau: 100
• Assay: ≥95.0%
• Form: powder
• Funktionelle Gruppe: carboxylic acid
• Lagertemp.: 2-8°C
• SMILES String: OC(CCOCCOCCOCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O)=O

Beschreibung

Anwendung

VH 032 amide-PEG₃-acid is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal carboxyl group, allowing rapid conjugation of amine containing linkers. A basic building block for development of a protein degrader library.

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Sonstige Hinweise

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Impact of linker length on the activity of PROTACs

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable