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Merck

731765

Sigma-Aldrich

Poly(ethylenglykol)-Methylether-Maleimid

average Mn 2,000, maleimide, methoxy, chemical modification reagent thiol reactive

Synonym(e):

Methoxy-PEG-maleimid, PEG-methylether-maleimid

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About This Item

Lineare Formel:
CH3O(CH2CH2O)nCH2CH2OC(O)CH2CH2CH2N[C(O)]2CHCH
UNSPSC-Code:
12162002
NACRES:
NA.23

Produktbezeichnung

Poly(ethylenglykol)-Methylether-Maleimid, average Mn 2,000

Form

solid

Qualitätsniveau

Mol-Gew.

average Mn 2,000

Eignung der Reaktion

reagent type: chemical modification reagent
reactivity: thiol reactive

mp (Schmelzpunkt)

48-52 °C

Mw/Mn

<1.1

Ω-Ende

maleimide

α-Ende

methoxy

Polymerarchitektur

shape: linear
functionality: monofunctional

Anwendung

Poly(ethylene glycol) methyl ether maleimide is a maleimide-functionalized poly(ethylene glycol). Due to the maleimide-functionalization, this material can be used to rapidly conjugate thiol-containing biomolecules, APIs, or targeting ligands.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Karina L Heredia et al.
Macromolecules, 42(7), 2360-2367 (2009-01-01)
In this report we describe a straightforward approach to synthesize polymers with end-groups that bind site-specifically to two different proteins. Telechelic biotin, maleimide poly(

Artikel

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

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