466964

4′-Fluor-2′-hydroxyacetophenon

98%

• Lineare Formel: FC₆H₃(OH)COCH₃
• CAS-Nummer: 1481-27-2
• Molekulargewicht: 154.14
• MDL-Nummer: MFCD00143203
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24870373
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 98%
• mp (Schmelzpunkt): 31-35 °C (lit.)
• SMILES String: CC(=O)c1ccc(F)cc1O
• InChI: 1S/C8H7FO2/c1-5(10)7-3-2-6(9)4-8(7)11/h2-4,11H,1H3
• InChIKey: HLTBTUXAMVOKIH-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

4′-Fluoro-2′-hydroxyacetophenone is a substituted acetophenone derivative. Biological Baeyer-Villiger oxidation of 4′-fluoro-2′-hydroxyacetophenone to 4-fluorocatechol by using whole cells of Pseudomonas fluorescens ACB has been reported. Its crystals belong to the monoclinic crystal system and space group P2₁/n.

Anwendung

Used recently in the preparation of medicinally active benzo[b]furans and thiophenes.

4′-Fluoro-2′-hydroxyacetophenone may be used in the preparation of series of 4′-fluoro-2′-hydroxychalcones, via aldol condensation with substituted aldehydes followed by cyclization with hydrazine hydrate.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315 - H319 - H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): 210.2 °F - closed cup
• Flammpunkt (°C): 99 °C - closed cup
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves