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5-Methoxy-psoralen

Name: 5-Methoxy-psoralen
Brand: ALDRICH

99%

Synonym(e):

4-Methoxyfuro[3,2-g]benzopyran-7-on, Bergapten, Geralen, Heraclin, Majudin

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About This Item

Empirische Formel (Hill-System):

C₁₂H₈O₄

CAS-Nummer:

484-20-8

Molekulargewicht:

216.19

Beilstein:

19560

EG-Nummer:

207-604-5

MDL-Nummer:

MFCD00010272

UNSPSC-Code:

12352103

PubChem Substanz-ID:

24856667

NACRES:

NA.23

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Slide 1 of 10

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Sigma-Aldrich

P8399

Psoralen

Supelco

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5-Methoxy-psoralen

Sigma-Aldrich

T6137

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Sigma-Aldrich

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Sigma-Aldrich

A4330

4′-Aminomethyltrioxsalen -hydrochlorid

Sigma-Aldrich

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1,1,1,3,3,3-Hexafluor-2-propanol

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W515809

7-Methoxycumarin

Assay

99%

mp (Schmelzpunkt)

190-193 °C (lit.)

SMILES String

COc1c2C=CC(=O)Oc2cc3occc13

InChI

1S/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H3

InChIKey

BGEBZHIAGXMEMV-UHFFFAOYSA-N

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Anwendung

5-Methoxypsoralen has been studied for its use in oral photochemotherapy in the treatment of psoriasis and other skin diseases.

Piktogramme

GHS08,GHS07

Signalwort

Warning

H-Sätze

H317,H341,H351

P-Sätze

P202 - P261 - P272 - P280 - P302 + P352 - P308 + P313

Gefahreneinstufungen

Carc. 2 - Muta. 2 - Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

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Sigma-Aldrich

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Sigma-Aldrich

SRE0027

Heparin Natriumsalz aus Schweinedarm

Antiproliferative activity and phototoxicity of some methyl derivatives of 5-methoxypsoralen and 5-methoxyangelicin.

M T Conconi et al.

Pharmacology & toxicology, 82(4), 193-198 (1998-05-19)

The in vitro antiproliferative activity and in vivo phototoxicity of some methyl derivatives of 5-methoxypsoralen and 5-methoxyangelicin, i.e. 4,4'-dimethyl-5-methoxyangelicin (compound I), 3,4'-dimethyl-5-methoxyangelicin (compound II), 4,4'-dimethyl-5-methoxypsoralen (compound III); and 3,4'-dimethyl-5-methoxypsoralen (compound IV), have been investigated. The effects of the compounds were

Rapid characterization of cross-links, mono-adducts, and non-covalent binding of psoralens to deoxyoligonucleotides by LC-UV/ESI-MS and IRMPD mass spectrometry.

Suncerae I Smith et al.

The Analyst, 135(5), 943-952 (2010-04-27)

Upon UV photoactivation, psoralen analogs form covalent mono-adducts and cross-links with DNA at thymine residues. Electrospray ionization mass spectrometric analysis allowed rapid and efficient determination of the reaction percentages of each psoralen analog with DNA duplexes containing different binding sites

5-Methoxypsoralen plus ultraviolet (UV) A is superior to medium-dose UVA1 in the treatment of severe atopic dermatitis: a randomized crossover trial.

S Tzaneva et al.

The British journal of dermatology, 162(3), 655-660 (2009-09-23)

Ultraviolet (UV) A1 and psoralen plus UVA (PUVA) are effective treatment options for severe atopic dermatitis (AD); however, their relative efficacy has not yet been determined in a head-to-head study. To compare UVA1 and oral 5-methoxypsoralen (5-MOP) plus UVA with

5-Methoxypsoralen. A review of its effects in psoriasis and vitiligo.

W McNeely et al.

Drugs, 56(4), 667-690 (1998-11-07)

5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation [psoralen plus UV (PUVA)] to manage psoriasis and vitiligo. In patients and volunteers, PUVA 5-methoxypsoralen causes a dose-related increase in cutaneous photosensitivity. However

Efficacy of psoralen plus ultraviolet A therapy vs. biologics in moderate to severe chronic plaque psoriasis: retrospective data analysis of a patient registry.

M Inzinger et al.

The British journal of dermatology, 165(3), 640-645 (2011-05-14)

Few studies have directly compared the clinical efficacy of psoralen plus ultraviolet A (PUVA) vs. biologics in the treatment of psoriasis. To compare the clinical efficacy of PUVA and biologic therapies for psoriasis under daily life conditions. Data from a

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Key Documents

5-Methoxy-psoralen

99%

About This Item

Empfohlene Produkte

Eigenschaften

Assay

mp (Schmelzpunkt)

SMILES String

InChI

InChIKey

Verwandte Kategorien

Beschreibung

Anwendung

Sicherheitshinweise

Piktogramme

Signalwort

H-Sätze

P-Sätze

Gefahreneinstufungen

Lagerklassenschlüssel

WGK

Flammpunkt (°F)

Flammpunkt (°C)

Persönliche Schutzausrüstung

Dokumentation

Analysenzertifikate (COA)

Besitzen Sie dieses Produkt bereits?

Kunden haben sich ebenfalls angesehen

Peer-Reviewed-Artikel

Protokolle und Artikel

Verwandter Inhalt

Technischer Dienst