144487
2-Amino-3-benzyloxypyridin
99%
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(2)
About This Item
Empirische Formel (Hill-System):
C12H12N2O
CAS-Nummer:
Molekulargewicht:
200.24
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352100
PubChem Substanz-ID:
NACRES:
NA.22
Empfohlene Produkte
Qualitätsniveau
Assay
99%
Form
solid
mp (Schmelzpunkt)
92-94 °C (lit.)
Funktionelle Gruppe
phenyl
SMILES String
Nc1ncccc1OCc2ccccc2
InChI
1S/C12H12N2O/c13-12-11(7-4-8-14-12)15-9-10-5-2-1-3-6-10/h1-8H,9H2,(H2,13,14)
InChIKey
NMCBWICNRJLKKM-UHFFFAOYSA-N
Angaben zum Gen
human ... MAPK14(1432)
Allgemeine Beschreibung
2-Amino-3-benzyloxypyridine on condensation with diethyl ethoxymethylene malonate affords 9-benzyloxy-3-ethoxycarbonylpyrido[1,2-a]pyrimidin-4-one.
Anwendung
2-Amino-3-benzyloxypyridine was used in the synthesis of 1-acetyl-2-[2-(3-benzyloxypyridinyl)]iminoimidazolidine.
Biochem./physiol. Wirkung
2-Amino-3-benzyloxypyridine is an inhibitor of mitogen-activated protein kinase p38α activity.
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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Synthesis of new heterocyclic phenols: 9-Hydroxypyrido [1, 2-a] pyrimidin-4-one and Derivatives.
Dennin F, et al.
Journal of Heterocyclic Chemistry, 28(5), 1287-1291 (1991)
J Chang-Fong et al.
Chemical & pharmaceutical bulletin, 48(5), 729-733 (2000-05-24)
In order to obtain possible veinotonic drugs acting through alpha2 receptor activation, we prepared clonidine analogues in which the 2-imino-imidazolidine was attached to various aliphatic or aromatic heterocycles. Among them, the two benzopyranic derivatives 16 and 22 exhibited interesting affinities
Jung-Eun Park et al.
European journal of medicinal chemistry, 141, 322-334 (2017-10-17)
Herein, we report synthesis and evaluation of new twenty six small molecules against β amyloid (Aβ)-induced opening of mitochondrial permeability transition pore (mPTP) using JC-1 assay which measures the change of mitochondrial membrane potential (ΔΨm). The neuroprotective effect of seventeen
Ahmed Elkamhawy et al.
European journal of medicinal chemistry, 128, 56-69 (2017-02-06)
Herein, we report a new series of aliphatic substituted pyridyl-urea small molecules synthesized as potential modulators for amyloid beta (Aβ) induced mitochondrial dysfunction. Their blocking activities against Aβ-induced mitochondrial permeability transition pore (mPTP) opening were evaluated by JC-1 assay which
Yuya Kodama et al.
Journal of medicinal chemistry, 56(22), 9342-9350 (2013-11-01)
In this study, we developed an assignment-free approach for rapid identification of ligand-binding sites in target proteins by using NMR. With a sophisticated cell-free stable isotope-labeling procedure that introduces (15)N- or (13)C-labels to specific atoms of target proteins, this approach
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
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