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NR3C1

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Synonyme:
GCCR, GCR, GR, GRL
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(2908) Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
  • Mouse(14815) nuclear receptor subfamily 3, group C, member 1
  • Rat(24413) nuclear receptor subfamily 3, group C, member 1
  • Zebrafish(553740) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • chicken(416343) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • dog(478047) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • domestic cat(692348) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • cow(281946) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • Horse(100061217) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • domestic cat(101080939) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • domestic guinea pig(100135583) nuclear receptor subfamily 3, group C, member 1
  • naked mole-rat(101722101) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • Domestic Rabbit(100008890) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • sheep(443412) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

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Small Molecule - Activator

Produktnummer
Beschreibung
Spezies
1-Methoxy-2-propyl-acetat, ReagentPlus®, ≥99.5%,
Spezies
human
Medroxyprogesteron-17-Acetat, ≥97% (HPLC),
Spezies
human, rat
Mifepriston, ≥98%,
Spezies
human, mouse, rat

Small Molecule - Agonist

Produktnummer
Beschreibung
Spezies
Cortisol -Lösung, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Spezies
human
Prednison, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
Prednison, ≥98%,
Spezies
human
Hydrocortisone 21-hemisuccinate sodium salt, powder, BioReagent, suitable for cell culture,
Spezies
human
Dexamethason-21-phosphat Dinatriumsalz, ≥98%,
Spezies
human

Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
6α-Methylprednisolon, ≥98%,
Spezies
human, rat
Hydrocortison 21-Acetat, ≥98% (HPLC),
Spezies
human
Mifepriston, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
Clobetasolpropionat, analytical standard,
Spezies
human, rat
Hydrocortison -acetat (Salz), meets USP testing specifications,
Spezies
human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-GR antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-NR3C1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunofluorescence
western blot
Anti-phospho-Glucocorticoid receptor Antibody, Ser226, from rabbit, purified by affinity chromatography,
Speziesreaktivität
human, mouse, rat
Anwendung
western blot
Anti-Glucocorticoid Receptor Antibody, serum, from rabbit,
Speziesreaktivität
bovine, canine, feline, horse, human, mouse, nonhuman primates
Anwendung
affinity binding assay
western blot
Anti-Glucocorticoid Receptor (Ab-2) Mouse mAb (BuGR2), lyophilized, clone BuGR2, Calbiochem®,
Speziesreaktivität
guinea pig, mouse, rabbit, rat, sheep
Anwendung

Small Molecule - Mixed Agonist/Antagonist

Produktnummer
Beschreibung
Spezies
Dexamethason, VETRANAL®, analytical standard,
Spezies
human
Medroxyprogesteron-17-Acetat, ≥97% (HPLC),
Spezies
human, rat
Dexamethason, powder, BioReagent, suitable for cell culture, ≥97%,
Spezies
mouse, rat, human
Dexamethason, ≥98% (HPLC), powder,
Spezies
mouse, rat, human
Dexamethason, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Spezies
mouse, rat, human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human NR3C1,
Spezies
human
MISSION® esiRNA, targeting mouse Nr3c1,
Spezies
mouse