Skip to Content
MilliporeSigma
HomeProductsPharma & Biopharma ManufacturingClarification & HarvestClarification Prefilters

Clarification Prefilters

Examples of clarification prefilters used in pharma and biopharma production

Clarigard® and Polygard® clarification prefilters remove particulates at different steps in biopharma production. These polypropylene filters are offered in both capsule and cartridge formats, with multiple sizes to fit different application needs.

  • Clarigard® filters have a 99.99% particle retention rating, protect downstream operations, and offer low extractables and broad chemical compatibility.
  • Polygard® filters provide high dirt-holding capacity with minimal differential pressure. These nominally rated filters can be used for particulate removal from liquids and gases in multiple applications. 

Related Product Resources

Product Selection

Brochure: Clarification Portfolio Guide

Product Specifications

Data Sheet: Polygard® CR Filters
Data Sheet: Polygard® CN Filters
Data Sheet: Clarigard®

Product Operations

Application Note: Generic Process of Virus-like Particle (VLP) Based Vaccine Manufacturing
Application Note: Generic Manufacturing Process of Foot & Mouth Disease Vaccines (FMDV)
Brochure: The Science of Managing Change for Filters

Related Product Categories
Filter Housings
Discover customizable Series 4000™ stainless steel filter housings for precise biopharmaceutical processes.
Clarification Filter Holders and Systems for Bioprocessing
Our flexible hardware and systems for disposable depth filters are ideal for clarification at pilot and process scales, featuring the modular Pod device that enables scale-up and scale-down within the same footprint.
Clarification Depth Filters & Pretreatment Solutions
Elevate your cell culture process: Employ Millistak+® and Clarisolve® filters for efficient upstream clarification and secondary polishing.
Related Applications
Monoclonal Antibody Manufacturing
Monoclonal antibody manufacturing is a highly templated approach used to produce mAb-based immunotherapies. Robust, scalable process solutions are required at every step to ensure high therapeutic concentration and process safety, while meeting speed-to-market and cost containment concerns.
Gene Therapy Manufacturing
Growing use of gene therapies is driving rapid innovation in an evolving global market. Manufacturers bringing new gene therapies to life face complex challenges, requiring an experienced partner capable of integrating vector manufacturing, testing, safety, process development, and regulatory compliance.
Antibody-Drug Conjugate (ADC) Manufacturing
Antibody-drug conjugation (ADC) technology uses monoclonal antibodies (mAbs) to deliver potent, highly active pharmaceutical ingredients (HPAPIs) to targeted cells. Learn about processes and areas of expertise required to advance your ADC to market.
Vaccine Manufacturing
From early phase development, through downstream purification to large scale vaccine production: learn more about vaccine process development and application expertise.
Blood Plasma Fractionation
Consistent, reliable performance is key to blood plasma fractionation, posing challenges to improve yield, maintain process economics, and manage regulatory requirements. Learn how the right partner can help fractionators to better serve patients globally with enhanced IgG, albumin, and Factor VIII products.
Classical Pharmaceutical Formulation & Manufacturing
Manufacturing the final dosage form of a small molecule drug requires robust quality and design in development of the formulation and production of the final product. Explore solutions and best practices to advance and accelerate small molecule pharmaceuticals, from development to commercialization.
Related Services
M Lab™ Collaboration Centers
M Lab™ Collaboration Centers offer in-person or virtual visits with experts to solve the challenges in your biopharma and pharma facilities. From upstream to downstream and through the final fill, our non-GMP facilities are resource hubs where you can explore, learn, and collaborate.
Sign In To Continue

To continue reading please sign in or create an account.

Don't Have An Account?