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Membrane Chromatography

Our Natrix® chromatography membrane technology provides a new level of downstream productivity and versatility. The macroporous structure, combined with high functional group density, enables high load capacity and excellent impurity removal at ultra-fast flow rates. With great performance in a single-use and scalable format, our innovative Natrix® products improve process economics and facility utilization. 

Natrix® Q strong anion exchange chromatography membrane for single-use biomolecule purification

Natrix® Q chromatography membrane

A high-capacity, high-throughput strong anion exchange membrane chromatography device designed for biomolecule purification, Natrix® Q chromatography membrane is a porous polyacrylamide hydrogel containing a high density of pendant quaternary ammonium (Q) binding groups directly polymerized within an inert, macroporous membrane scaffold. The interconnected pore structure and high functional group density enables fast flow rates with impressive throughput to extremely high loads while maintaining excellent impurity removal across a wide range of buffer conditions. Natrix® Q delivers improvements in productivity, flexibility, economic utility, and process robustness for any bioprocess design.

 

RELATED PRODUCT RESOURCES

Product Selection

Guide: Chromatography Product Selection Guide
Guide: Biochromatography Portfolio Guide
Guide: Natrix® Q Chromatography Membrane
Guide: Natrix® Q Micro

Product Specification

Guide: Natrix® Q Chromatography Membrane Best Practices Guide

Product Operations

Data Sheet: Natrix® Q Chromatography Membrane - For single-use, scalable purification
Application Note: Comparison of process-related impurity clearance for membrane adsorbers and resin-based chromatography technologies
Application Note: Robust, Load Independent Viral Clearance in Monoclonal Antibody Purification with Natrix® Q Chromatography Membrane
Article: Driving Value in the Evolution Toward Continuous Monoclonal Antibody Processing
Brochure: What's Next: Exploring the Future of Bioprocessing Together
Webinar: Membrane Chromatography Solutions for Single-Use, Intensified mAb Purification
Webinar: High Productivity Membrane Chromatography: Enabling the Next Generation Bioprocessing Paradigm

Related Product Categories
Chromatography Systems for Bioprocessing
Single-use and multi-use chromatography systems are critical for the separation of your valuable molecules. We provide standard and custom systems from pilot to process-scale, offering robust and consistent performance with the processing flexibility you need.
Affinity Chromatography Resins
Affinity chromatography is often used during the capture phase to isolate the target molecule and reduce process volume. Our range of affinity resins includes Protein A, anti-A and anti-B, and metal chelate resin, designed for high throughput and cost-effective purification.
Ion Exchange Chromatography Resins
Ion exchange (IEX) chromatography separates biomolecules based on the difference in charge between the target molecule and chromatography resin.
Clarification Prefilters
Elevate pharma process purity with efficient clarification prefilters. Safeguard downstream operations from impurities.
Tangential Flow Filtration Devices
Elevate Filtration Precision: Our tangential flow products ensure purity for mAbs, vaccines, and more, scaling from single-use to multi-use.
Buffers & pH Adjusters
Our broad portfolio of buffer materials manufactured according to GMP guidelines includes excipients specifically for drug formulation and manufacturing, including high-risk applications. Whether your product is a small or large molecule drug, we offer high-quality buffers and pH adjusters with regulatory support.
RELATED APPLICATIONS
Monoclonal Antibody Manufacturing
Monoclonal antibody manufacturing is a highly templated approach used to produce mAb-based immunotherapies. Robust, scalable process solutions are required at every step to ensure high therapeutic concentration and process safety, while meeting speed-to-market and cost containment concerns.
Removing Viruses From Your Downstream mAb Process
Downstream viral clearance is accomplished by several steps that either remove or inactivate viruses. Typically, this includes chromatography, chemical treatment, and filtration. A key requirement of viral safety assessment is demonstrating the effectiveness of viral clearance across different steps.
Pharma & Biopharma Startup Hub
Your new molecule or therapy begins its journey here. Find solutions and resources to navigate your path to successful drug discovery, development, and commercialization.
Viral Vector Contract Development and Manufacturing
Producing new viral vector drugs demands specialized expertise that can be prohibitively expensive and time-consuming to develop. Partnership with an experienced contract manufacturer can integrate compliance, safety, and process development on a global scale, eliminating time and risk mitigation concerns.
Viral Vector Downstream Processing
Demand for new gene therapies is challenging manufacturers to accelerate development. By replacing legacy purification technologies with more scalable alternatives, downstream operations can produce greater economies while delivering higher yield and throughput.
RELATED SERVICES
Emprove® Chromatography
The Emprove® Chromatography portfolio streamlines resin selection and qualification for biopharmaceutical manufacturers, built to address process-specific needs at steps from early to late downstream.

Highlights

Webinar: High Productivity Membrane Chromatography: Enabling the Next Generation Bioprocessing Paradigm
Webinar: High Productivity Membrane Chromatography: Enabling the Next Generation Bioprocessing Paradigm

Advantages of a fully single-use membrane-based purification process as well as high capacity flow through polishing with an inventive membrane absorber.

Webinar: Downstream Process Intensification for Virus Purification Using Membrane Chromatography
Webinar: Downstream Process Intensification for Virus Purification Using Membrane Chromatography

Improve virus purification yield, productivity & manufacturing flexibility while reducing costs via process intensification using membrane chromatography. 

Webinar: Membrane Chromatography Solutions for Single-Use, Intensified mAb Purification
Webinar: Membrane Chromatography Solutions for Single-Use, Intensified mAb Purification

Learn the benefits of a novel Protein A affinity membrane, used as a high productivity, truly single-use chromatography platform for intensified mAb purification

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