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Key Documents

SAB3500383

Sigma-Aldrich

Anti-CXCR4 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-CXCR4

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About This Item

MDL number:
MFCD01092337
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

NP_003458

UniProt accession no.

P61073

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CXCR4(7852)

General description

C-X-C motif chemokine receptor 4 (CXCR4) is encoded by the gene mapped to human chromosome 2q22.1. The gene codes for a protein with seven transmembrane regions. The encoded protein is expressed on the surface of T-cells, B-cells, monocytes, neutrophils and dendritic cells.

Immunogen

CXCR4 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human CXCR4.

Application

Anti-CXCR4 antibody produced in rabbit has been used in western blot analysis and indirect ELISA.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

C-X-C motif chemokine receptor 4 (CXCR4) is specific for stromal cell-derived factor-1. It plays a vital role in regulation of immune response in various immune cell types. CXCR4 interacts with CD4 (cluster of differentiation 4) and permits human immunodeficiency virus type 1 (HIV-1) entry and infection in to the cells. Polymorphism in the gene is associated with the development of Juvenile idiopathic arthritis (JIA). In addition, mutation in the gene increases the risk of susceptibility to cardiovascular diseases (CVDs).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500383.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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ABT-888 and quinacrine induced apoptosis in metastatic breast cancer stem cells by inhibiting base excision repair via adenomatous polyposis coli.
Siddharth S, et al.
DNA Repair, 45, 44-55 (2016)
Genetic variation of CXCR4 and risk of coronary artery disease: epidemiological study and functional validation of CRISPR/Cas9 system.
Runmin G, et al.
Oncotarget, 9(18), 14077?14083-14077?14083 (2018)
Withaferin A targeting both cancer stem cells and metastatic cancer stem cells in the UP-LN1 carcinoma cell model.
T Lai-Lei, et al.
Journal of Cancer Metastasis and Treatment, 2(1), 29-40 (2016)
CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.
Endres M J, et al.
Cell, 87(4), 745-756 (1996)
Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.
Finkel T H, et al.
BMC Medical Genetics, 17(1), 24-24 (2016)
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