Anti-PCDH12 antibody produced in rabbit

PCDH12 antibody was raised against a 17 amino acid peptide near the amino terminus of human PCDH12.

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Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 12 (PCDH12) was initially identified through PCR screening of mouse heart microvascular endothelial cell RNA; further experiments revealed its mRNA to be strongly expressed in highly vascularized organs such as lung and kidney, in addition to glycogen-rich trophoblasts in the placenta. PCDH12-null mice are viable and fertile, but show reduced placental and embryonic sizes when compared to wild-type mice. Further studies showed significant expression changes in 2,289 genes, including those involved in tissue morphogenesis, angiogenesis, cell-matrix adhesion and migration, immune response and chromatin remodeling. This antibody is predicted to not cross-react with PCDH18.

The action of this antibody can be blocked using blocking peptide SBP3500017.

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

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