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I1646

Sigma-Aldrich

IL-3 human

≥97% (HPLC and SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

hIL-3, IL-3

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About This Item

MDL number:
MFCD00147276
UNSPSC Code:
12352202
NACRES:
NA.77

product name

Interleukin-3 human, IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

200

recombinant

expressed in E. coli

assay

≥97% (HPLC and SDS-PAGE)

form

lyophilized powder

potency

≤1.0 ng/mL ED50/EC50

quality

endotoxin tested

mol wt

15 kDa

packaging

pkg of 10 and 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

≤0.1 EU/μg

UniProt accession no.

P08700

storage temp.

−20°C

Gene Information

human ... IL3(3562)

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Biochem/physiol Actions

Interleukin-3 (IL-3) is a multifunctional protein, originally called colony forming unit-stimulating activity (CFU-SA), and is produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 has been shown to induce colony formation of macrophages, neutrophils, mast cells, and megakaryocytes from agar-suspended bone marrow cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and to induce IgG secretion from activated B cells. Other synonyms for IL-3 include pan-specific hemopoietin, multicolony stimulating factor, mast cell growth factor, burst promoting activity, histamine-producing cell stimulating factor, P cell stimulating factor, and WEHI-3 factor.

Physical form

Lyophilized with no additives. Sterile filtered through a 0.2 μm filter.

Analysis Note

The biological activity is measured by the dose-dependent stimulation of the proliferation of human TF-1 cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Bingrui Wang et al.
Cell discovery, 8(1), 41-41 (2022-05-10)
Ribosomal protein dysfunction causes diverse human diseases, including Diamond-Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the mechanisms underlying ribosomopathies, which are characterized by tissue-specific defects, are still poorly understood. In the present study, we
S Yousefi et al.
Allergy, 70(9), 1184-1188 (2015-06-05)
Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report
Hai Zhou et al.
Thrombosis and haemostasis, 113(5), 1021-1034 (2015-01-09)
Impaired megakaryocyte maturation and insufficient platelet production have been shown to participate in the pathogenesis of immune thrombocytopenia (ITP). Our previous study demonstrated that low expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in megakaryocytes contributed to impaired platelet production
Jinhua Liu et al.
Nature communications, 9(1), 4386-4386 (2018-10-24)
In addition to serving as a prosthetic group for enzymes and a hemoglobin structural component, heme is a crucial homeostatic regulator of erythroid cell development and function. While lncRNAs modulate diverse physiological and pathological cellular processes, their involvement in heme-dependent
Kerstin Kapp et al.
Molecular therapy. Nucleic acids, 3, e170-e170 (2014-06-25)
Toll-like receptors are sensing modulators of the innate immune system. One member of this protein family, Toll-like receptor (TLR)-9, is increasingly being investigated as therapeutic target for infectious diseases and cancer. Double-Stem Loop ImmunoModulator (dSLIM) is a new TLR-9 agonist
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