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G5003

Sigma-Aldrich

α-Glucosidase from Saccharomyces cerevisiae

greener alternative

Type I, lyophilized powder, ≥10 units/mg protein (using p-nitrophenyl α-D-glucoside as substrate.)

Synonym(s):

α-D-Glucosidase, α-D-Glucoside glucohydrolase, Maltase from yeast

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About This Item

CAS Number:
9001-42-7
Enzyme Commission number:
3.2.1.20 (BRENDA, IUBMB)
EC Number:
232-604-7
MDL number:
MFCD00081321
UNSPSC Code:
12352204
NACRES:
NA.54

type

Type I

Quality Level

200

form

lyophilized powder

specific activity

≥10 units/mg protein (using p-nitrophenyl α-D-glucoside as substrate.)

contains

phosphate buffer salts and EDTA as balance

composition

Protein, ≥50%

greener alternative product characteristics

Waste Prevention
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

UniProt accession no.

P38158
P53341

foreign activity

β-Glucosidase, α−galactosidase and β−galactosidase ≤0.1%

greener alternative category

, Enabling

relevant disease(s)

diabetes (management of non-insulin-dependent diabetes mellitus)

storage temp.

−20°C

Gene Information

bakers yeast ... MAL12(853209) , MAL32(852602)

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General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency and waste prevention when used in starch hydrolysis research. For more information see the article in biofiles.

Application

α-glucosidase is used for the determination of α-amylase and the synthesis of various 1′-O-sucrose and 1-O-fructose esters. It was also used in the measurement of glycosidase inhibition.
For the determination of α-amylase and the synthesis of various 1′-O-sucrose and 1-O-fructose esters

Biochem/physiol Actions

α-glucosidase hydrolyzes carbohydrates by acting on 1,4-α linkages. Inhibition of α-glucosidase is a prominent target in the management of non-insulin-dependent diabetes mellitus.
Hydrolysis of terminal, non-reducing 1→4-linked D-glucose residues with release of D-glucose.

Packaging

Sold on basis of p-nitrophenyl α-D-glucoside units.

Unit Definition

One unit will liberate 1.0 μmole of D-glucose from p-nitrophenyl α-D-glucoside per min at pH 6.8 at 37 °C.

Analysis Note

Protein determined by biuret.

Other Notes

View more information on enzymes for complex carbohydrate analysis at www.sigma-aldrich.com/enzymeexplorer

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Natnicha Wutthiwong et al.
Journal of fungi (Basel, Switzerland), 7(5) (2021-06-03)
Daldiniaeschsone A (1), a rare tricyclic polyketide having a chromone unit fused to a δ-lactone and its symmetrical 6,6'-biphenyl dimer, daldiniaeschsone B (2), together with three known compounds (3-5), were isolated from a plant-derived endophytic fungus, Daldinia eschscholtzii SDBR-CMUNKC745. Their
Gitishree Das et al.
International journal of nanomedicine, 14, 4741-4754 (2019-08-29)
Ipomoea batatas (L.) Lam.(Ib) has high content of various beneficial nutrients which helps in improving and maintaining human health. It is well known as a functional food and also a valuable source of unique natural products. It contains various phenolic
M Bianchi
Anatomischer Anzeiger, 169(5), 351-366 (1989-01-01)
In 13 horses from both sexes, between 5 months and 18 years of age, in good nutritional state, statistical evaluations of fat cell sizes were performed in 16 body regions. From direct and indirect measurements referred to the cell diameter
A D Baron
Diabetes research and clinical practice, 40 Suppl, S51-S55 (1998-09-18)
Fasting blood glucose level is usually used to diagnose diabetes, but is not a good predictor of postprandial hyperglycaemia, which is a more accurate measure of the metabolic defect underlying type 2 diabetes. Postprandial blood glucose levels may be elevated
Sae Rom Park et al.
Food chemistry, 257, 128-134 (2018-04-07)
α-Glucosidase is an enzyme that plays a key role in raising blood sugar level and is considered a good target for developing drugs to treat type 2 diabetes. This study was performed to evaluate the inhibition of the catalytic reaction
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