MISSION^® RNAi Licenses

These licenses are relevant for all MISSION products:

Lentiviral Licenses

This product is for non-clinical research use only. Use of this product for Commercial Purposes requires a license from Sigma-Aldrich^® Corporation. The purchase of this product conveys to the buyer the nontransferable right to use the purchased amount of the product and components of the product in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The buyer cannot sell or otherwise transfer (a) this product; (b) its components; or (c) materials made using this product or its components to a third party, or otherwise use this product or its components or materials made using this product or its components for Commercial Purposes. Commercial Purposes means any activity by a party for consideration, but excludes not-for-profit core facilities providing services within their own research institutions at cost.

This product is licensed under U.S. Pat. Nos. 6,682,907, 7,981,671, 8,093,042, 8,367,068, 8,460,678, 8,512,994 and foreign equivalents from Institut Pasteur, Paris, France and is provided for internal research purposes only. Use of this product or technology for any commercial production or sale of lentiviral tools or products requires a license from Sigma-Aldrich Co. LLC. 3050 Spruce Street, St. Louis, MO 63103, USA. Sigma-Aldrich Co. LLC has the exclusive worldwide rights for licensing the DNA Flap technology covered under the above patents. Use of this product or technology for any commercial development for therapeutic application requires a license from Institute Pasteur, 25-28 Rue du Dr. Roux, 75015 Paris, France.

This product is licensed under U.S. Pat. Nos. 6,312,682; 6,669,936; 6,235,522; and 6,924,123 and foreign equivalents from Oxford BioMedica (UK) Ltd., Oxford, UK, and is provided for use in academic and commercial in vitro and in vivo research for elucidating gene function, and for validating potential gene products and pathways for drug discovery and development, but excludes any use of LentiVector^® technology for: creating transgenic birds for the purpose of producing useful or valuable proteins in the eggs of such transgenic birds, the delivery of gene therapies, and for commercial production of therapeutic, diagnostic or other commercial products not intended for research use where such products do not consist of or incorporate a lentiviral vector. Information about licenses for commercial uses excluded under this license is available from Oxford BioMedica (UK), Ltd., Medawar Center, Oxford Science Park, Oxford OX4 4GA UK enquiries@oxfordbiomedica.co.uk or BioMedica Inc., 11622 El Camino Real #100, San Diego CA 92130-2049 USA. LentiVector is a registered US and European Community trademark of Oxford BioMedica plc.

This product (based upon the lentikat system) is sub-licensed from Invitrogen Corporation under U.S. Patent Nos. 5,994,136 and 6,165,782 and corresponding patents and applications in other countries for internal research purposes only. Use of this technology for gene therapy applications or bioprocessing other than for nonhuman research use requires a license from Cell Genesys, Inc. Please contact Cell Genesys, Inc. at 342 Lakeside Drive, Foster City, California 94404 USA. Use of this technology to make or sell products or offer services for consideration in the research market requires a license from Invitrogen Corporation, 1600 Faraday Ave., Carlsbad, CA 92008 USA.

Any Sigma-Aldrich^® lentiviral backbone-containing products containing a specific genetic component (WPRE) are licensed from the Salk Institute for Biological Studies and covered under the following patents: U.S. Patent No. 6,136,597; U.S. Patent No. 6,284,469; U.S. Patent No. 6,312,912; and U.S. Patent No. 6,287,814.

These licenses are relevant for all MISSION products but SHP001:

This product is for non-clinical research use only. It is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic, therapeutic or high throughput drug discovery purposes (the screening of more than 10,000 compounds per day) is prohibited. This product is sold under license from Invitrogen Corporation. In order to obtain a license to use this product for these commercial purposes, contact The Regents of the University of California. This product or the use of this product is covered by U.S. Patent No. 5,624,803 owned by The Regents of the University of California.

This Product is covered by US and foreign patent applications or patents and other proprietary intellectual property rights owned by CSHL ("CSHL shRNA IP Rights"), including U.S. Patent Nos. 8,153,776, 8,202,846, 8,383,599, 8,829,264, and EP1546174.

Subject to acceptance and all terms and conditions of this License, sale of the Product to Buyer by Sigma-Aldrich, Co. (acting under its license, an "Authorized Sale") conveys to Buyer only the nonexclusive, nontransferable right (with no right to sublicense) under the shRNA IP Rights to use the Product solely for Customer’s internal research purposes, and only at its facility where the Product is delivered by Sigma-Aldrich, Co.

The Product is for research use only and may not be used in vitro or in vivo for any diagnostic, preventative, therapeutic or vaccine application, or used (directly or indirectly) in humans for any purpose.

*Non-Profit Buyers. If Buyer is a Non-Profit Entity, then the following additional restrictions will apply:

Customer obtains no right to use, develop or otherwise exploit the product for any commercial purpose.

*Commercial Buyers. If Buyer is a Commercial Entity, then the following additional restrictions will apply:

A Product sale is an Authorized Sale only if Buyer has already entered into a separate written agreement that has been executed by CSHL or Hairpin Technologies, that covers the CSHL shRNA IP Rights, and that is then currently in effect. Any delivery or transfer of Product to Customer outside of an Authorized Sale is void, conveys no implied or express right under this license and Customer will immediately return Product to Sigma-Aldrich for a refund.

"Commercial Entity" means any entity or organization other than a Non-Profit Entity.

"CSHL" means Cold Spring Harbor Laboratory.

“Hairpin Technologies” means Hairpin Technologies, Inc. located at 2200 Smithtown Avenue, Ronkonkoma, NY 11779, www.hairpintechnologies.com.

"Non-Profit Entity" means any college, university or governmental entity (including without limitation, governmental and quasi-governmental institutes and research laboratories), or any non-profit scientific, research or educational organization of the type described in section 501(c)(3) of the Internal Revenue Code or qualified under a state non-profit organization statute.

"Product" means a product (including, without limitation, expression vectors encoding a shRNA, the design, manufacture or use of which (in whole or in part) is the subject of the shRNA IP Rights, and is deemed to include all components, progeny, reproductions, modified versions and other derivatives thereof.

This license is subject to a license from CSHL or Hairpin Technologies, and CSHL and Hairpin Technologies reserves all other rights under its license. For information on licensing rights for Commercial Entities, including use of this product for purposes other than research and trial licenses, please contact Hairpin Technologies, Inc. at info@hairpintechnologies.com or call (631) 881-0844.

These licenses are relevant for all MISSION products but SHC001, SHC001H, SHC001V, SHC003, SHC003H, SHC003V, SHP001:

Licensed under Carnegie Institution US Patent 6,506,559 and Massachusetts Institute of Technology and for laboratory and commercial research use only.

This product is licensed under agreement with Benitec Australia Ltd. and CSIRO as co-owners of U.S. Pat. No. 6,573,099 and foreign counterparts, for use in research to understand, diagnose, monitor, treat and prevent human diseases and disorders, including the use of animals for such research use, except that use of ddRNAi as a therapeutic agent or as a method of disease treatment, prevention, diagnosis or for disease monitoring is excluded. Information regarding licenses to these patents for use of ddRNAi as a therapeutic agent or for other uses excluded under this license is available from Benitec at licensing@benitec.com. Information about licenses for the use of ddRNAi in other fields, is available from CSIRO at pi.csiro.au/RNAi.

This product is licensed under European Patents 1144623, 1214945 and foreign equivalents from Alnylam Pharmaceuticals, Inc., Cambridge, USA and is provided only for use in academic and commercial research whose purpose is to elucidate gene function, including research to validate potential gene products and pathways for drug discovery and development and to screen non-siRNA based compounds (but excluding the evaluation or characterization of this product as the potential basis for a siRNA-based drug) and not for any other commercial purposes. Information about licenses for commercial use (including discovery and development of siRNA-based drugs) is available from Alnylam Pharmaceuticals, Inc., 300 Third Street, Cambridge, MA 02142, USA.

This license is relevant for all MISSION products but SHC002, SHC002H, SHC002V, SHC003, SHC003H, SHC003V,
SHC004, SHC004V, SHP001:

The MISSION shRNA Library of The RNAi Consortium is produced and distributed under license from the Massachusetts Institute of Technology.

This licenses is relevant for MISSION products SHC003, SHC003H, SHC003V, SHC203, SHC203V, SHC010,
SHC010V, SHC011, SHC011V, SHC012, SHC012V, SHC013, SHC013V, SHC014, SHC014V, SHC015, SHC015V, SHXC01:

This product contains a proprietary nucleic acid coding for a proprietary fluorescent protein(s) intended to be used for research purposes only. Any use of the proprietary nucleic acid or fluorescent proteins coding by proprietary nucleic acids other than for research use is strictly prohibited. USE IN ANY OTHER APPLICATION REQUIRES A LICENSE FROM EVROGEN. To obtain such a license, please contact Evrogen at license@evrogen.com.

This license is relevant for MISSION products containing the WPRE, including the TRC2 clones, SHC201, SHC201V, SHC202,
SHC202V, SHC203, SHC203V, SHC204, SHC204V:

Purchaser Notification:

Licensee has a license to sell the Product containing WPRE, under the terms described below. Any use of WPRE outside of Licensee’s Product or the Product’s intended use, requires a license as detailed below. Before using the Product containing WPRE, please read the following license agreement. If you do not agree to be bound by its terms, contact Licensee within 10 days for authorization to return the unused Product containing WPRE and to receive a full credit.

Licensee grants you a non-exclusive license to use the enclosed Product containing WPRE in its entirety for its intended research use. The Product containing WPRE is being transferred to you in furtherance of, and reliance on, such license. Any use of WPRE outside of Licensee’s Product or the Product’s intended use including for Commercial Purposes, requires a license from the Salk Institute for Biological Studies. Commercial Purposes means any activity by a party for consideration, but excludes not-for-profit core facilities providing services within their own research institutions at cost. This license agreement is effective until terminated. You may terminate it at any time by destroying all Products containing WPRE in your control. It will also terminate automatically if you fail to comply with the terms and conditions of the license agreement. You shall, upon termination of the license agreement, destroy all Products containing WPRE in your control, and so notify Licensee in writing. This License shall be governed in its interpretation and enforcement by the laws of the State of California.

Contact for WPRE Licensing:

The Salk Institute for Biological Studies
10010 North Torrey Pines Road
La Jolla, CA 92037
Attn.: Office of Technology Management
Phone: (858) 453-4100 extension 1703
Fax: (858) 546-8093