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TDG

thymine-DNA glycosylase

Synonimy:
hTDG
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(6996) Summary: The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]
  • Mouse(21665) thymine DNA glycosylase
  • Rat(114521) thymine-DNA glycosylase
  • Zebrafish(553789) thymine-DNA glycosylase
  • dog(475448) thymine-DNA glycosylase
  • domestic cat(101082502) thymine-DNA glycosylase
  • Horse(100053458) thymine-DNA glycosylase
  • chicken(395510) thymine-DNA glycosylase
  • cow(517825) thymine-DNA glycosylase
  • sheep(101123623) thymine-DNA glycosylase
  • naked mole-rat(101703457) thymine-DNA glycosylase
  • domestic guinea pig(100724604) thymine-DNA glycosylase

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Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-TDG antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
western blot
Anti-TDG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
immunohistochemistry
Przeciwciało przeciw glikozylazie tyminy-DNA, from rabbit, purified by affinity chromatography,
Reaktywność gatunkowa
human, mouse
Zastosowanie
immunocytochemistry
western blot

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting human TDG,
Gatunek
human
MISSION® esiRNA, targeting mouse Tdg,
Gatunek
mouse