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Merck

TDG

thymine-DNA glycosylase

Sinonimi:
hTDG
Specie:
ID UniProtKB:
ID gene:
  • Human(6996) Summary: The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]
  • Mouse(21665) thymine DNA glycosylase
  • Rat(114521) thymine-DNA glycosylase
  • Zebrafish(553789) thymine-DNA glycosylase
  • dog(475448) thymine-DNA glycosylase
  • domestic cat(101082502) thymine-DNA glycosylase
  • Horse(100053458) thymine-DNA glycosylase
  • chicken(395510) thymine-DNA glycosylase
  • cow(517825) thymine-DNA glycosylase
  • sheep(101123623) thymine-DNA glycosylase
  • naked mole-rat(101703457) thymine-DNA glycosylase
  • domestic guinea pig(100724604) thymine-DNA glycosylase

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Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-TDG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry
Anti-Thymine-DNA Glycosylase Antibody, from rabbit, purified by affinity chromatography,
Reattività con
human, mouse
Applicazione
immunocytochemistry
western blot
Anti-TDG antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
western blot

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting mouse Tdg,
Specie
mouse
MISSION® esiRNA, targeting human TDG,
Specie
human