TDG
thymine-DNA glycosylase
Synonyms:
hTDG
Species:
Human TDG (6996), Mouse Tdg (21665), Rat Tdg (114521), Zebrafish tdg (553789), dog TDG (475448), domestic cat TDG (101082502), Horse TDG (100053458), chicken TDG (395510), cow TDG (517825), sheep TDG (101123623) ...More
UniProtKB ID:
Gene ID:
- Human(6996) Summary: The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]
- Mouse(21665) thymine DNA glycosylase
- Rat(114521) thymine-DNA glycosylase
- Zebrafish(553789) thymine-DNA glycosylase
- dog(475448) thymine-DNA glycosylase
- domestic cat(101082502) thymine-DNA glycosylase
- Horse(100053458) thymine-DNA glycosylase
- chicken(395510) thymine-DNA glycosylase
- cow(517825) thymine-DNA glycosylase
- sheep(101123623) thymine-DNA glycosylase
- naked mole-rat(101703457) thymine-DNA glycosylase
- domestic guinea pig(100724604) thymine-DNA glycosylase
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Thymine-DNA Glycosylase Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse
Application
immunocytochemistry
western blot
western blot
Anti-TDG antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-TDG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry