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SOCS2

suppressor of cytokine signaling 2

Synonyms:
CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
Species:
Human SOCS2 (8835), Mouse Socs2 (216233), Rat Socs2 (84607), Zebrafish socs2 (562062), domestic cat SOCS2 (101080980), dog SOCS2 (482603), chicken SOCS2 (395219), domestic guinea pig Socs2 (100716104), cow SOCS2 (338437), sheep SOCS2 (101115017)
UniProtKB ID:
O14508, A8K3D1, O14542, O95102, Q9UKS5
Gene ID:
  • Human(8835) Summary: This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
  • Mouse(216233) suppressor of cytokine signaling 2
  • Rat(84607) suppressor of cytokine signaling 2
  • Zebrafish(562062) suppressor of cytokine signaling 2
  • domestic cat(101080980) suppressor of cytokine signaling 2
  • dog(482603) suppressor of cytokine signaling 2
  • chicken(395219) suppressor of cytokine signaling 2
  • domestic guinea pig(100716104) suppressor of cytokine signaling 2
  • cow(338437) suppressor of cytokine signaling 2
  • sheep(101115017) suppressor of cytokine signaling 2

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB5701688
Anti-SOCS2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
SAB1404633
Monoclonal Anti-SOCS2, (C-terminal) antibody produced in mouse, clone 3E7, ascites fluid,
Species Reactivity
human
Application
ELISA

esiRNA

Product Number
Description
Species
EHU001181
MISSION® esiRNA, targeting human SOCS2,
Species
human