SMG7
SMG7 nonsense mediated mRNA decay factor
Synonyms:
C1orf16, EST1C, SGA56M
Species:
Human SMG7 (9887), Mouse Smg7 (226517), Rat Smg7 (360855), Thale Cress SMG7 (832060), Zebrafish smg7 (565575), dog SMG7 (480035), domestic cat SMG7 (101088454), Horse SMG7 (100055474), chicken SMG7 (424444), naked mole-rat Smg7 (101717612) ...More
UniProtKB ID:
Gene ID:
- Human(9887) Summary: This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
- Mouse(226517) Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
- Rat(360855) SMG7 nonsense mediated mRNA decay factor
- Thale Cress(832060) EST1 domain protein SMG7
- Zebrafish(565575) Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
- dog(480035) smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
- domestic cat(101088454) smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
- Horse(100055474) smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
- chicken(424444) Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
- naked mole-rat(101717612) smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
- Domestic Rabbit(100339791) smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
- domestic guinea pig(100733436) smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
- cow(537131) smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
- sheep(101105838) smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SMG7 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-SMG7 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry