SMC1A
structural maintenance of chromosomes 1A
Synonyms:
CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Species:
Human SMC1A (8243), Mouse Smc1a (24061), Rat Smc1a (63996), Zebrafish smc1a (559665), chicken SMC1A (395187), dog SMC1A (480928), domestic cat SMC1A (101090170), cow SMC1A (282370), sheep SMC1A (101120550), domestic guinea pig Smc1a (100723138)
UniProtKB ID:
Gene ID:
- Human(8243) Summary: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq, Jul 2008]
- Mouse(24061) structural maintenance of chromosomes 1A
- Rat(63996) structural maintenance of chromosomes 1A
- Zebrafish(559665) structural maintenance of chromosomes 1A
- chicken(395187) structural maintenance of chromosomes 1A
- dog(480928) structural maintenance of chromosomes 1A
- domestic cat(101090170) structural maintenance of chromosomes 1A
- cow(282370) structural maintenance of chromosomes 1A
- sheep(101120550) structural maintenance of chromosomes 1A
- domestic guinea pig(100723138) structural maintenance of chromosomes 1A
- naked mole-rat(101713253) structural maintenance of chromosomes 1A
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-SMC1L1 antibody produced in mouse, clone 1B9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-SMC1A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Anti-phospho-SMC1 (pSer957) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-SMC1A (pSer957) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Rabbit anti-Phospho SMC1 (S957) Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
western blot