SMAD1
SMAD family member 1
Synonyms:
BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1
Species:
Human SMAD1 (4086), Mouse Smad1 (17125), Rat Smad1 (25671), cow SMAD1 (540488), sheep SMAD1 (443229), domestic guinea pig Smad1 (100727257), naked mole-rat Smad1 (101725903), Domestic Rabbit SMAD1 (100341544), Zebrafish smad1 (30628), domestic cat SMAD1 (101085713) ...More
UniProtKB ID:
Gene ID:
- Human(4086) Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
- Mouse(17125) SMAD family member 1
- Rat(25671) SMAD family member 1
- cow(540488) SMAD family member 1
- sheep(443229) SMAD family member 1
- domestic guinea pig(100727257) SMAD family member 1
- naked mole-rat(101725903) SMAD family member 1
- Domestic Rabbit(100341544) SMAD family member 1
- Zebrafish(30628) MAD homolog 1 (Drosophila)
- domestic cat(101085713) SMAD family member 1
- Horse(100033850) SMAD family member 1
- dog(475456) SMAD family member 1
- chicken(395680) SMAD family member 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-Smad1 (pSer465) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho Smad1/Smad5/Smad8 (Ser463/465), from rabbit, purified by affinity chromatography,
Species Reactivity
xenopus, human, mink, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-SMAD1 Antibody, clone AS22, clone AS22, from mouse,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot
western blot
Anti-SMAD1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-SMAD1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Proteins
Product Number
Description
Species
SMAD1, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
esiRNA
Product Number
Description
Species