SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Synonyms:
FBL1, FBXL1, FLB1, p45
Species:
Human SKP2 (6502), Mouse Skp2 (27401), Rat Skp2 (294790), fruit fly Skp2 (40548), Zebrafish skp2 (563708), Horse SKP2 (100053697), domestic cat SKP2 (101099275), dog SKP2 (489228), chicken SKP2 (427437), cow SKP2 (519018) ...More
UniProtKB ID:
Gene ID:
- Human(6502) Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
- Mouse(27401) S-phase kinase-associated protein 2 (p45)
- Rat(294790) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- fruit fly(40548) CG9772 gene product from transcript CG9772-RA
- Zebrafish(563708) S-phase kinase-associated protein 2 (p45)
- Horse(100053697) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- domestic cat(101099275) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- dog(489228) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- chicken(427437) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- cow(519018) S-phase kinase-associated protein 2 (p45)
- sheep(101109483) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- naked mole-rat(101706248) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- domestic guinea pig(100720705) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-SKP2 antibody produced in mouse, clone 6G9D10, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-Skp2 Antibody, clone 1B13 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, human, monkey, mouse, porcine
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-SKP2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
proximity ligation assay
western blot
western blot
Anti-SKP2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-SKP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Proteins
Product Number
Description
Species
SCF-Skp2 Protein Complex, Active, 10 µg, Active complex of five (5) full length, recombinant human enzymes: Skp1, Skp2, Cul1, Rbx1 & Cks1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.,
Species
human