SHANK3
SH3 and multiple ankyrin repeat domains 3
Synonyms:
DEL22q13.3, PROSAP2, PSAP2, SCZD15, SPANK-2
Species:
Human SHANK3 (85358), Mouse Shank3 (58234), Rat Shank3 (59312), Zebrafish shank3 (793484), Horse SHANK3 (100056993), domestic cat SHANK3 (101085990), dog SHANK3 (474456), chicken SHANK3 (101666327), chicken SHANK3 (101748950), cow SHANK3 (512428) ...More
UniProtKB ID:
Gene ID:
- Human(85358) Summary: This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar 2012]
- Mouse(58234) SH3/ankyrin domain gene 3
- Rat(59312) SH3 and multiple ankyrin repeat domains 3
- Zebrafish(793484) SH3 and multiple ankyrin repeat domains protein 3
- Horse(100056993) SH3 and multiple ankyrin repeat domains 3
- domestic cat(101085990) SH3 and multiple ankyrin repeat domains 3
- dog(474456) SH3 and multiple ankyrin repeat domains 3
- chicken(101666327) SH3 and multiple ankyrin repeat domains 3
- chicken(101748950) SH3 and multiple ankyrin repeat domains 3
- cow(512428) SH3 and multiple ankyrin repeat domains 3
- sheep(101119297) SH3 and multiple ankyrin repeat domains 3
- naked mole-rat(101722405) SH3 and multiple ankyrin repeat domains 3
- domestic guinea pig(100723583) SH3 and multiple ankyrin repeat domains 3
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SHANK3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-SHANK3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-Shank1/Shank3 - Atto 594 antibody produced in mouse, clone S367-51, purified immunoglobulin,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Shank1/Shank3 - Hrp antibody produced in mouse, clone S367-51, purified immunoglobulin,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Shank1/Shank3 antibody produced in mouse, clone S367-51, purified immunoglobulin,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
esiRNA
Product Number
Description
Species