ROCK1
Rho-associated, coiled-coil containing protein kinase 1
Synonyms:
P160ROCK, ROCK-I
Species:
Human ROCK1 (6093), Mouse Rock1 (19877), Rat Rock1 (81762), Zebrafish rock1 (100329779), dog ROCK1 (480181), Horse ROCK1 (100034056), chicken ROCK1 (373970), domestic guinea pig Rock1 (100718968), naked mole-rat Rock1 (101710589), Domestic Rabbit ROCK1 (100009220) ...More
UniProtKB ID:
Gene ID:
- Human(6093) Summary: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq, Jul 2008]
- Mouse(19877) Rho-associated coiled-coil containing protein kinase 1
- Rat(81762) Rho-associated coiled-coil containing protein kinase 1
- Zebrafish(100329779) Rho-associated, coiled-coil containing protein kinase 1
- dog(480181) Rho-associated, coiled-coil containing protein kinase 1
- Horse(100034056) Rho-associated, coiled-coil containing protein kinase 1
- chicken(373970) Rho-associated, coiled-coil containing protein kinase 1
- domestic guinea pig(100718968) Rho-associated, coiled-coil containing protein kinase 1
- naked mole-rat(101710589) Rho-associated, coiled-coil containing protein kinase 1
- Domestic Rabbit(100009220) Rho-associated, coiled-coil containing protein kinase 1
- cow(785911) Rho-associated, coiled-coil containing protein kinase 1
- sheep(100294662) Rho-associated, coiled-coil containing protein kinase 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ROCK1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-ROCK1 antibody produced in mouse, clone 2E2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Monoclonal Anti-ROCK1 antibody produced in mouse, clone 1H4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-ROCK1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-ROCK1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Proteins
Product Number
Description
Species
ROCK1 (17-535), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
ROKα/ROCK-II Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human ROCK-II residues 11-552, for use in Kinase Assays.,
Species
human
ROKβ/ROCK-I Protein, active, 10 µg, Active, N-terminal His6-tagged, recombinant, human ROCK-I amino acids 17-535, autoactivated by incubating with Mg/ATP & redialysed to remove excess ATP. For use in Kinase Assays.,
Species
human
ROKα/ROCK-II Protein, active, rat, 10 µg, Active, rat, N-terminal, His-tagged, fusion protein corresponding to amino acids 2-543 of rat ROKa/ROCK-II. For use in Kinase Assays.,
Species
rat
esiRNA
Product Number
Description
Species