RB1
retinoblastoma 1
Synonyms:
OSRC, RB, p105-Rb, pRb, pp110
Species:
Human RB1 (5925), Mouse Rb1 (19645), Rat Rb1 (24708), cow RB1 (534712), sheep RB1 (100144755), Domestic Rabbit RB1 (100357431), naked mole-rat Rb1 (101703701), domestic guinea pig Rb1 (100716297), Zebrafish rb1 (777733), chicken RB1 (386582) ...More
UniProtKB ID:
Gene ID:
- Human(5925) Summary: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
- Mouse(19645) retinoblastoma 1
- Rat(24708) retinoblastoma 1
- cow(534712) retinoblastoma 1
- sheep(100144755) retinoblastoma 1
- Domestic Rabbit(100357431) retinoblastoma 1
- naked mole-rat(101703701) retinoblastoma 1
- domestic guinea pig(100716297) retinoblastoma 1
- Zebrafish(777733) retinoblastoma 1
- chicken(386582) retinoblastoma 1
- dog(476915) retinoblastoma 1
- domestic cat(101101356) retinoblastoma 1
- Horse(100057080) retinoblastoma 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Retinoblastoma antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Retinoblastoma antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-Retinoblastoma antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-Retinoblastoma antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-Retinoblastoma, C-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
immunofluorescence
immunohistochemistry
Kits
Product Number
Description
Species
CpG WIZ™ RB1 - Methylation specific PCR assay, MSP, performed using the CpGenome DNA Modification Kit & the CpG WIZ RB1 Amplification Kit, permits sensitive detection of altered DNA.,
Species
human
Proteins
Product Number
Description
Species
Retinoblastoma protein human, recombinant, expressed in insect cells, ≥70% (SDS-PAGE),
Species
human
Retinoblastoma Protein (aa 773-928), Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli.,
Species
human