RB1
retinoblastoma 1
Synonyms:
OSRC, RB, p105-Rb, pRb, pp110
Species:
Human RB1 (5925), Mouse Rb1 (19645), Rat Rb1 (24708), cow RB1 (534712), sheep RB1 (100144755), Domestic Rabbit RB1 (100357431), naked mole-rat Rb1 (101703701), domestic guinea pig Rb1 (100716297), Zebrafish rb1 (777733), chicken RB1 (386582) ...More
UniProtKB ID:
Gene ID:
- Human(5925) Summary: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
- Mouse(19645) retinoblastoma 1
- Rat(24708) retinoblastoma 1
- cow(534712) retinoblastoma 1
- sheep(100144755) retinoblastoma 1
- Domestic Rabbit(100357431) retinoblastoma 1
- naked mole-rat(101703701) retinoblastoma 1
- domestic guinea pig(100716297) retinoblastoma 1
- Zebrafish(777733) retinoblastoma 1
- chicken(386582) retinoblastoma 1
- dog(476915) retinoblastoma 1
- domestic cat(101101356) retinoblastoma 1
- Horse(100057080) retinoblastoma 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-RB1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, rabbit, rat
Application
western blot
Anti-RB1 (Ab-780) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-phospho-RB1 (pSer780) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-Retinoblastoma (pSer811) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-p-Rb-Ser807/811 Antibody, clone 3J7 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey, rat
Application
flow cytometry
immunocytochemistry
immunohistochemistry
inhibition assay
western blot
immunocytochemistry
immunohistochemistry
inhibition assay
western blot
Kits
Product Number
Description
Species
CpG WIZ™ RB1 - Methylation specific PCR assay, MSP, performed using the CpGenome DNA Modification Kit & the CpG WIZ RB1 Amplification Kit, permits sensitive detection of altered DNA.,
Species
human
Proteins
Product Number
Description
Species
Retinoblastoma protein human, recombinant, expressed in insect cells, ≥70% (SDS-PAGE),
Species
human
Retinoblastoma Protein (aa 773-928), Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli.,
Species
human