PTAFR
platelet-activating factor receptor
Synonyms:
PAFR
Species:
Human PTAFR (5724), Mouse Ptafr (19204), Rat Ptafr (58949), chicken PTAFR (428209), dog PTAFR (487336), domestic cat PTAFR (101085906), cow PTAFR (518283), Goat PTAFR (100860976), sheep PTAFR (101104560), sheep PTAFR (443041) ...More
UniProtKB ID:
Gene ID:
- Human(5724) Summary: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
- Mouse(19204) platelet-activating factor receptor
- Rat(58949) platelet-activating factor receptor
- chicken(428209) platelet-activating factor receptor
- dog(487336) platelet-activating factor receptor
- domestic cat(101085906) platelet-activating factor receptor
- cow(518283) platelet-activating factor receptor
- Goat(100860976) platelet-activating factor receptor
- sheep(101104560) platelet-activating factor receptor
- sheep(443041) platelet-activating factor receptor
- domestic guinea pig(100720710) platelet-activating factor receptor
- naked mole-rat(101711912) platelet-activating factor receptor
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Small Molecule - Antagonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PTAFR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-PTAFR antibody produced in mouse, purified immunoglobulin,
Species Reactivity
human, mouse
Application
western blot