PHKB
phosphorylase kinase, beta
Synonyms:
Species:
Human PHKB (5257), Mouse Phkb (102093), Rat Phkb (361377), Zebrafish phkb (569706), Horse PHKB (100050040), domestic cat PHKB (101088635), dog PHKB (478139), chicken PHKB (415741), cow PHKB (511783), sheep PHKB (101110353) ...More
UniProtKB ID:
Gene ID:
- Human(5257) Summary: Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.[provided by RefSeq, Feb 2010]
- Mouse(102093) phosphorylase kinase beta
- Rat(361377) phosphorylase kinase, beta
- Zebrafish(569706) phosphorylase kinase, beta
- Horse(100050040) phosphorylase kinase, beta
- domestic cat(101088635) phosphorylase kinase, beta
- dog(478139) phosphorylase kinase, beta
- chicken(415741) phosphorylase kinase, beta
- cow(511783) phosphorylase kinase, beta
- sheep(101110353) phosphorylase kinase, beta
- Domestic Rabbit(100009137) phosphorylase kinase, beta
- naked mole-rat(101706280) phosphorylase kinase, beta
- domestic guinea pig(100724099) phosphorylase kinase, beta
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-PHKB antibody produced in mouse, clone 2E9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-PHKB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence