PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
Synonyms:
APP-1, APP1, PABP4, iPABP
Species:
Human PABPC4 (8761), Mouse Pabpc4 (230721), Rat Pabpc4 (298510), Zebrafish pabpc4 (321035), dog PABPC4 (482464), Horse PABPC4 (100054235), cow PABPC4 (534576), domestic cat PABPC4 (101095427), chicken PABPC4 (419674), domestic guinea pig Pabpc4 (100717325) ...More
UniProtKB ID:
Gene ID:
- Human(8761) Summary: Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
- Mouse(230721) poly(A) binding protein, cytoplasmic 4
- Rat(298510) poly(A) binding protein, cytoplasmic 4
- Zebrafish(321035) poly(A) binding protein, cytoplasmic 4 (inducible form)
- dog(482464) poly(A) binding protein, cytoplasmic 4 (inducible form)
- Horse(100054235) poly(A) binding protein, cytoplasmic 4 (inducible form)
- cow(534576) poly(A) binding protein, cytoplasmic 4 (inducible form)
- domestic cat(101095427) poly(A) binding protein, cytoplasmic 4 (inducible form)
- chicken(419674) poly(A) binding protein, cytoplasmic 4 (inducible form)
- domestic guinea pig(100717325) poly(A) binding protein, cytoplasmic 4 (inducible form)
- naked mole-rat(101712162) poly(A) binding protein, cytoplasmic 4 (inducible form)
- Domestic Rabbit(100340846) poly(A) binding protein, cytoplasmic 4 (inducible form)
- sheep(101118742) poly(A) binding protein, cytoplasmic 4 (inducible form)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PABPC4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
guinea pig, horse, human, rabbit, rat
Application
western blot
Anti-PABPC4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PABPC4 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-PABPC4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot