ORC1
origin recognition complex, subunit 1
Synonyms:
HSORC1, ORC1L, PARC1
Species:
Human ORC1 (4998), Mouse Orc1 (18392), Rat Orc1 (313479), fruit fly Orc1 (35686), chicken ORC1 (424640), dog ORC1 (475351), domestic cat ORC1 (101090883), cow ORC1 (513523), Zebrafish orc1 (554509), sheep ORC1 (101115076) ...More
UniProtKB ID:
Gene ID:
- Human(4998) Summary: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
- Mouse(18392) origin recognition complex, subunit 1
- Rat(313479) origin recognition complex, subunit 1
- fruit fly(35686) Origin recognition complex subunit 1
- chicken(424640) origin recognition complex, subunit 1
- dog(475351) origin recognition complex, subunit 1
- domestic cat(101090883) origin recognition complex, subunit 1
- cow(513523) origin recognition complex, subunit 1
- Zebrafish(554509) origin recognition complex, subunit 1
- sheep(101115076) origin recognition complex, subunit 1
- domestic guinea pig(100724157) origin recognition complex, subunit 1
- naked mole-rat(101713340) origin recognition complex, subunit 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Rabbit anti-ORC1 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
western blot
Anti-ORC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
esiRNA
Product Number
Description
Species