OPN4
opsin 4
Synonyms:
MOP
Species:
Human OPN4 (94233), Mouse Opn4 (30044), Rat Opn4 (192223), naked mole-rat Opn4 (101702306), domestic guinea pig Opn4 (100724179), sheep OPN4 (101111250), chicken OPN4 (423609), dog OPN4 (611027), domestic cat OPN4 (493921), cow OPN4 (515152)
UniProtKB ID:
Gene ID:
- Human(94233) Summary: Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(30044) opsin 4 (melanopsin)
- Rat(192223) opsin 4
- naked mole-rat(101702306) opsin 4
- domestic guinea pig(100724179) opsin 4
- sheep(101111250) opsin 4
- chicken(423609) opsin 4
- dog(611027) opsin 4
- domestic cat(493921) opsin 4
- cow(515152) opsin 4
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Melanopsin Antibody, clone 1F8.1, clone 1F8.1, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-OPN4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
western blot