OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
Synonyms:
IFI-4, OIAS, OIASI
Species:
Human OAS1 (4938), domestic guinea pig Oas1 (100721851), naked mole-rat Oas1 (101699903), sheep OAS1 (101110181), sheep OAS1 (100294650), dog OAS1 (608778), Horse OAS1 (100034147), domestic cat OAS1 (101087875)
UniProtKB ID:
Gene ID:
- Human(4938) Summary: This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- domestic guinea pig(100721851) 2'-5'-oligoadenylate synthetase 1, 40/46kDa
- naked mole-rat(101699903) 2'-5'-oligoadenylate synthetase 1, 40/46kDa
- sheep(101110181) 2'-5'-oligoadenylate synthetase 1, 40/46kDa
- sheep(100294650) 2'-5'-oligoadenylate synthetase 1, 40/46kDa
- dog(608778) 2'-5'-oligoadenylate synthetase 1, 40/46kDa
- Horse(100034147) 2'-5'-oligoadenylate synthetase 1, 40/46kDa
- domestic cat(101087875) 2'-5'-oligoadenylate synthetase 1, 40/46kDa
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-OAS1 Antibody, clone 1D11.1, clone 1D11.1, from mouse,
Species Reactivity
human
Application
western blot
Anti-OAS1, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-OAS1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-OAS1 Antibody, clone 1N2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
ELISA
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
Anti-OAS1 (ab3) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot