NCF4
neutrophil cytosolic factor 4, 40kDa
Synonyms:
NCF, P40PHOX, SH3PXD4
Species:
Human NCF4 (4689), Mouse Ncf4 (17972), Rat Ncf4 (500904), sheep NCF4 (101122939), naked mole-rat Ncf4 (101699188), Domestic Rabbit NCF4 (100009359), domestic guinea pig Ncf4 (100729267), Zebrafish ncf4 (403014), chicken NCF4 (418052), domestic cat NCF4 (101095507) ...More
UniProtKB ID:
Gene ID:
- Human(4689) Summary: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(17972) neutrophil cytosolic factor 4
- Rat(500904) neutrophil cytosolic factor 4
- sheep(101122939) neutrophil cytosolic factor 4, 40kDa
- naked mole-rat(101699188) neutrophil cytosolic factor 4, 40kDa
- Domestic Rabbit(100009359) neutrophil cytosolic factor 4, 40kDa
- domestic guinea pig(100729267) neutrophil cytosolic factor 4, 40kDa
- Zebrafish(403014) neutrophil cytosolic factor 4
- chicken(418052) neutrophil cytosolic factor 4, 40kDa
- domestic cat(101095507) neutrophil cytosolic factor 4, 40kDa
- cow(507859) neutrophil cytosolic factor 4, 40kDa
- Horse(100069566) neutrophil cytosolic factor 4, 40kDa
- dog(481277) neutrophil cytosolic factor 4, 40kDa
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-NCF4 antibody produced in mouse, clone 3C10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
Anti-NCF4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-NCF4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
guinea pig, horse, human, rat
Application
western blot
Anti-NCF4/P40PHOX antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-NCF4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Proteins
Product Number
Description
Species