MVB12B
multivesicular body subunit 12B
Synonyms:
C9orf28, FAM125B
Species:
Human MVB12B (89853), Mouse Mvb12b (72543), Rat Mvb12b (362118), naked mole-rat Mvb12b (101707948), domestic guinea pig Mvb12b (100728526), cow MVB12B (617416)
UniProtKB ID:
Gene ID:
- Human(89853) Summary: The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
- Mouse(72543) multivesicular body subunit 12B
- Rat(362118) multivesicular body subunit 12B
- naked mole-rat(101707948) multivesicular body subunit 12B
- domestic guinea pig(100728526) multivesicular body subunit 12B
- cow(617416) multivesicular body subunit 12B
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MVB12B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
esiRNA
Product Number
Description
Species