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Merck

MARCH1

membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase

Synonyms:
MARCH-I, RNF171
Species:
Human MARCH1 (55016), Mouse March1 (72925), Rat March1 (361135), chicken MARCH1 (422420), cow MARCH1 (617247), dog MARCH1 (612618), domestic cat MARCH1 (101098865), sheep MARCH1 (101106078), naked mole-rat March1 (101724772), domestic guinea pig March1 (100722498)
UniProtKB ID:
Q8TCQ1, D3DP29, Q9NWR0
Gene ID:
  • Human(55016) Summary: MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]
  • Mouse(72925) membrane-associated ring finger (C3HC4) 1
  • Rat(361135) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
  • chicken(422420) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
  • cow(617247) membrane-associated ring finger (C3HC4) 1
  • dog(612618) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
  • domestic cat(101098865) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
  • sheep(101106078) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
  • naked mole-rat(101724772) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
  • domestic guinea pig(100722498) membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB2101432
Anti-MARCH1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
WH0055016M2
Monoclonal Anti-MARCH1 antibody produced in mouse, clone 3D2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA