MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
Synonyms:
FLH21957, HGK, MEKKK4, NIK
Species:
Human MAP4K4 (9448), Mouse Map4k4 (26921), Rat Map4k4 (301363), chicken MAP4K4 (418714), cow MAP4K4 (509109), domestic cat MAP4K4 (101081214), dog MAP4K4 (481331), naked mole-rat Map4k4 (101707800), domestic guinea pig Map4k4 (100723651), sheep MAP4K4 (101109789)
UniProtKB ID:
Gene ID:
- Human(9448) Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- Mouse(26921) mitogen-activated protein kinase kinase kinase kinase 4
- Rat(301363) mitogen-activated protein kinase kinase kinase kinase 4
- chicken(418714) mitogen-activated protein kinase kinase kinase kinase 4
- cow(509109) mitogen-activated protein kinase kinase kinase kinase 4
- domestic cat(101081214) mitogen-activated protein kinase kinase kinase kinase 4
- dog(481331) mitogen-activated protein kinase kinase kinase kinase 4
- naked mole-rat(101707800) mitogen-activated protein kinase kinase kinase kinase 4
- domestic guinea pig(100723651) mitogen-activated protein kinase kinase kinase kinase 4
- sheep(101109789) mitogen-activated protein kinase kinase kinase kinase 4
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MAP4K4, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-MAP4K4 antibody produced in mouse, clone 2D4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
ANTI-MAP4K4 antibody produced in mouse, clone 3D9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-MAP4K4 Mouse mAb (4A5), liquid, clone 4A5, Calbiochem®,
Species Reactivity
human
Application
Anti-MAP4K4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Proteins
Product Number
Description
Species
HGK (1-328), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human