LILRB1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
Synonyms:
CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7
Species:
UniProtKB ID:
Gene ID:
- Human(10859) Summary: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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ELISA
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CD85j antibody produced in mouse, clone GHI/75,
Species Reactivity
human
Application
flow cytometry
Anti-LILRB1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
esiRNA
Product Number
Description
Species