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Merck

IL6R

interleukin 6 receptor

Synonymes:
CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(3570) Summary: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]
  • Rat(24499) interleukin 6 receptor
  • Zebrafish(100135755) interleukin 6 receptor
  • cow(507359) interleukin 6 receptor
  • domestic cat(101085689) interleukin 6 receptor
  • dog(612271) interleukin 6 receptor
  • domestic guinea pig(100730490) interleukin 6 receptor
  • naked mole-rat(101704925) interleukin 6 receptor
  • sheep(101103369) interleukin 6 receptor

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Monoclonal Anti-IL6R antibody produced in mouse, clone 1E11, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
Anti-CD126 Antibody, clone B-R6, clone B-R6, Chemicon®, from mouse,
Espèces réactives
human
Application
ELISA
flow cytometry

immunohistochemistry

immunoprecipitation (IP)
Anti-IL-6R Antibody, clone 1D19 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, monkey
Application
affinity binding assay
flow cytometry

immunocytochemistry

immunohistochemistry

western blot
Monoclonal Anti-IL6R antibody produced in mouse, clone 2G6, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
Anti-IL6R antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot

Proteins

Référence du produit
Description
Espèce(s)
sIL-6 Receptor alpha human, recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human IL6R,
Espèce(s)
human