HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
Synonyms:
HNRPU, SAF-A, U21.1, hnRNP U
Species:
Human HNRNPU (3192), Mouse Hnrnpu (51810), Rat Hnrnpu (117280), chicken HNRNPU (421492), dog HNRNPU (480100), cow HNRNPU (539950), Horse HNRNPU (100062482), domestic cat HNRNPU (101091585), domestic guinea pig Hnrnpu (100725944), naked mole-rat Hnrnpu (101726650)
UniProtKB ID:
Gene ID:
- Human(3192) Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
- Mouse(51810) heterogeneous nuclear ribonucleoprotein U
- Rat(117280) heterogeneous nuclear ribonucleoprotein U
- chicken(421492) heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
- dog(480100) heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
- cow(539950) heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
- Horse(100062482) heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
- domestic cat(101091585) heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
- domestic guinea pig(100725944) heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
- naked mole-rat(101726650) heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
- sheep(101107118) heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-hnRNP-U antibody, Mouse monoclonal, clone 3G6, purified from hybridoma cell culture,
Species Reactivity
human, monkey
Application
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
immunoprecipitation (IP)
microarray
western blot
Anti-HNRNPU, affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunohistochemistry
Anti-HNRNPU antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-HNRNPU antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-hnRNP U Antibody, clone 3G6, clone 3G6, from mouse,
Species Reactivity
human
Application
ELISA
immunocytochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunoprecipitation (IP)
western blot