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HIRA

histone cell cycle regulator

Synonyms:
DGCR1, TUP1, TUPLE1
Species:
Human HIRA (7290), Mouse Hira (15260), Rat Hira (363849), Zebrafish hira (568076), fruit fly Hira (31680), cow HIRA (511514), Horse HIRA (100052845), domestic cat HIRA (101098170), dog HIRA (486424), Thale Cress HIRA (823578) ...More
UniProtKB ID:
P54198, Q05BU9, Q8IXN2
Gene ID:
  • Human(7290) Summary: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
  • Mouse(15260) histone cell cycle regulation defective homolog A (S. cerevisiae)
  • Rat(363849) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • Zebrafish(568076) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • fruit fly(31680) CG12153 gene product from transcript CG12153-RA
  • cow(511514) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • Horse(100052845) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • domestic cat(101098170) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • dog(486424) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • Thale Cress(823578) protein HIRA
  • chicken(374074) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • sheep(101120607) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • Domestic Rabbit(100352472) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1300755
Anti-HIRA (center) antibody produced in rabbit, saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
SAB1400286
Anti-HIRA antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
04-1488
Anti-HIRA Antibody, clone WC119, clone WC119, from mouse,
Species Reactivity
human, mouse
Application
immunoprecipitation (IP)
western blot
SAB5702629
Anti-HIRA Antibody, clone 6Q7Y6, Rabbit Monoclonal, ,
Species Reactivity
human
Application
western blot
HPA050714
Anti-HIRA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

esiRNA

Product Number
Description
Species
EMU032731
MISSION® esiRNA, targeting mouse Hira,
Species
mouse
EHU061801
MISSION® esiRNA, targeting human HIRA, C22ORF39,
Species
human