GRM8
glutamate receptor, metabotropic 8
Synonyms:
GLUR8, GPRC1H, MGLUR8, mGlu8
Species:
Human GRM8 (2918), Mouse Grm8 (14823), Rat Grm8 (60590), chicken GRM8 (427853), cow GRM8 (538360), Horse GRM8 (100071655), dog GRM8 (482270), sheep GRM8 (101108742), Domestic Rabbit GRM8 (100328635), domestic guinea pig Grm8 (100725321)
UniProtKB ID:
Gene ID:
- Human(2918) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
- Mouse(14823) glutamate receptor, metabotropic 8
- Rat(60590) glutamate receptor, metabotropic 8
- chicken(427853) glutamate receptor, metabotropic 8
- cow(538360) glutamate receptor, metabotropic 8
- Horse(100071655) glutamate receptor, metabotropic 8
- dog(482270) glutamate receptor, metabotropic 8
- sheep(101108742) glutamate receptor, metabotropic 8
- Domestic Rabbit(100328635) glutamate receptor, metabotropic 8
- domestic guinea pig(100725321) glutamate receptor, metabotropic 8
- naked mole-rat(101697666) glutamate receptor, metabotropic 8
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Small Molecule - Agonist
Small Molecule - Antagonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-mGluR8 Antibody, serum, from guinea pig,
Species Reactivity
bovine, chimpanzee, dog, human, monkey, mouse, rat
Application
immunohistochemistry
Anti-Metabotropic Glutamate Receptor 8 Antibody, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunohistochemistry