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Merck

GREM1

gremlin 1, DAN family BMP antagonist

Synonimy:
CKTSF1B1, DAND2, DRM, GREMLIN, IHG-2
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(26585) Summary: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(23892) gremlin 1
  • Rat(50566) gremlin 1
  • chicken(395826) gremlin 1
  • cow(539079) gremlin 1
  • domestic cat(101096735) gremlin 1
  • dog(487475) gremlin 1
  • Goat(100860969) gremlin 1
  • sheep(101102396) gremlin 1
  • domestic guinea pig(100730568) gremlin 1, DAN family BMP antagonist
  • naked mole-rat(101720734) gremlin 1, DAN family BMP antagonist

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ELISA

Numer produktu
Opis
Gatunek
Mouse Gremlin-1 ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Gatunek
mouse

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
ANTI-GREMLIN (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reaktywność gatunkowa
human, mouse
Zastosowanie
immunohistochemistry
western blot
Monoclonal Anti-GREM1 antibody produced in mouse, clone 2C9, ascites fluid, solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
Anti-Grem1 antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
bovine, canine, goat, guinea pig, horse, human, mouse, rabbit, rat, zebrafish
Zastosowanie
western blot
Przeciwciało anty-Gremlin-1, klon 2H1.1, clone 2H1.1, from mouse,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
Anti-Grem1 (C-terminal) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
bovine, canine, goat, guinea pig, horse, human, mouse, rabbit, zebrafish
Zastosowanie
western blot

Proteins

Numer produktu
Opis
Gatunek
GREMLIN-1 human, recombinant, expressed in CHO cells, ≥90% (SDS-PAGE), ≥90% (HPLC),
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting mouse Grem1,
Gatunek
mouse
MISSION® esiRNA, targeting human GREM1,
Gatunek
human