GCLC
glutamate-cysteine ligase, catalytic subunit
Synonyms:
GCL, GCS, GLCL, GLCLC
Species:
Human GCLC (2729), Mouse Gclc (14629), Rat Gclc (25283), Zebrafish gclc (326857), chicken GCLC (421894), dog GCLC (609822), Horse GCLC (100056731), cow GCLC (512468), domestic cat GCLC (101096568), fruit fly Gclc (53581) ...More
UniProtKB ID:
Gene ID:
- Human(2729) Summary: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
- Mouse(14629) glutamate-cysteine ligase, catalytic subunit
- Rat(25283) glutamate-cysteine ligase, catalytic subunit
- Zebrafish(326857) glutamate-cysteine ligase, catalytic subunit
- chicken(421894) glutamate-cysteine ligase, catalytic subunit
- dog(609822) glutamate-cysteine ligase, catalytic subunit
- Horse(100056731) glutamate-cysteine ligase, catalytic subunit
- cow(512468) glutamate-cysteine ligase, catalytic subunit
- domestic cat(101096568) glutamate-cysteine ligase, catalytic subunit
- fruit fly(53581) Glutamate-cysteine ligase catalytic subunit
- domestic guinea pig(100726181) glutamate-cysteine ligase, catalytic subunit
- naked mole-rat(101718793) glutamate-cysteine ligase, catalytic subunit
- sheep(101114822) glutamate-cysteine ligase, catalytic subunit
- Domestic Rabbit(100342383) glutamate-cysteine ligase, catalytic subunit
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-GCLC antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Anti-GCLC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-GCLC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-GCLC antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-GCLC antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species