GCK
glucokinase (hexokinase 4)
Synonyms:
FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
Species:
Human GCK (2645), Mouse Gck (103988), Rat Gck (24385), domestic guinea pig Gck (100717630), naked mole-rat Gck (101721664), sheep GCK (101117412), Zebrafish gck (751668), domestic cat GCK (100037406), cow GCK (616576), Horse GCK (100051836) ...More
UniProtKB ID:
Gene ID:
- Human(2645) Summary: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]
- Mouse(103988) glucokinase
- Rat(24385) glucokinase
- domestic guinea pig(100717630) glucokinase (hexokinase 4)
- naked mole-rat(101721664) glucokinase (hexokinase 4)
- sheep(101117412) glucokinase (hexokinase 4)
- Zebrafish(751668) glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
- domestic cat(100037406) glucokinase (hexokinase 4)
- cow(616576) glucokinase (hexokinase 4)
- Horse(100051836) glucokinase (hexokinase 4)
- dog(606490) glucokinase (hexokinase 4)
- chicken(430370) glucokinase (hexokinase 4)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-GCK antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-Glucokinase (GCK) Antibody, clone 4K9D5, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunoprecipitation (IP)
western blot
western blot
Anti-GCK antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot
western blot
Monoclonal Anti-GCK, (C-terminal) antibody produced in mouse, clone 1G10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Monoclonal Anti-GCK antibody produced in mouse, clone 3C7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
esiRNA
Product Number
Description
Species