FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
Synonyms:
CD174, FT3B, FucT-III, LE, Les
Species:
Human FUT3 (2525), sheep FUT3 (101108745), naked mole-rat Fut3 (101727627), Thale Cress FUT3 (843783)
UniProtKB ID:
Gene ID:
- Human(2525) Summary: The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
- sheep(101108745) fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
- naked mole-rat(101727627) fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
- Thale Cress(843783) fucosyltransferase 3
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Lewis x Mouse mAb (P12), liquid, clone P12, Calbiochem®,
Species Reactivity
human
Application
Anti-FUT3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry