Pular para o conteúdo
Merck

E2F4

E2F transcription factor 4, p107/p130-binding

Sinônimos:
E2F-4
Espécies:
ID UniProtKB:
ID do gene:
  • Human(1874) Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
  • Mouse(104394) E2F transcription factor 4
  • Rat(100360427) E2F transcription factor 4, p107/p130-binding
  • Zebrafish(406741) E2F transcription factor 4
  • chicken(769430) E2F transcription factor 4, p107/p130-binding
  • dog(611243) E2F transcription factor 4, p107/p130-binding
  • cow(525428) E2F transcription factor 4, p107/p130-binding
  • domestic cat(101098911) E2F transcription factor 4, p107/p130-binding
  • sheep(101106963) E2F transcription factor 4, p107/p130-binding
  • naked mole-rat(101716696) E2F transcription factor 4, p107/p130-binding
  • domestic guinea pig(100735380) E2F transcription factor 4, p107/p130-binding

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-E2F4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
immunofluorescence
Anti-E2F4 antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Aplicação
immunohistochemistry
western blot
Anti-E2F-4 Antibody, clone GG22-2A6, clone GG22-2A6, Upstate®, from mouse,
Reatividade de espécies
human, mouse, rat
Aplicação
ChIP
immunoprecipitation (IP)

western blot
Anti-E2F4 Antibody, clone 3O6Y9, Rabbit Monoclonal, ,
Reatividade de espécies
mouse
Aplicação
western blot
Anti-E2F4 Antibody, clone LLF4-2, clone LLF4-2, from mouse,
Reatividade de espécies
human, mouse
Aplicação
immunohistochemistry
western blot

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human E2F4,
Espécies
human
MISSION® esiRNA, targeting mouse E2f4,
Espécies
mouse