DIO3
deiodinase, iodothyronine, type III
Synonyms:
5DIII, D3, DIOIII, TXDI3
Species:
Human DIO3 (1735), Mouse Dio3 (107585), Rat Dio3 (29475), chicken DIO3 (395939), cow DIO3 (494549), Horse DIO3 (100146344), domestic cat DIO3 (101094186), dog DIO3 (612596), sheep DIO3 (100142657), Domestic Rabbit DIO3 (100357267)
UniProtKB ID:
Gene ID:
- Human(1735) Summary: The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
- Mouse(107585) deiodinase, iodothyronine type III
- Rat(29475) deiodinase, iodothyronine, type III
- chicken(395939) deiodinase, iodothyronine, type III
- cow(494549) deiodinase, iodothyronine, type III
- Horse(100146344) deiodinase, iodothyronine, type III
- domestic cat(101094186) deiodinase, iodothyronine, type III
- dog(612596) deiodinase, iodothyronine, type III
- sheep(100142657) deiodinase, iodothyronine, type III
- Domestic Rabbit(100357267) deiodinase, iodothyronine, type III
- naked mole-rat(101697914) deiodinase, iodothyronine, type III
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Dio3 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, primate
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
ANTI-DIO3 (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-DIO3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence