DCTN1
dynactin 1
Synonyms:
DAP-150, DP-150, P135
Species:
Human DCTN1 (1639), Mouse Dctn1 (13191), Rat Dctn1 (29167), sheep DCTN1 (101116037), Domestic Rabbit DCTN1 (100346609), domestic guinea pig Dctn1 (100714202), naked mole-rat Dctn1 (101703706), chicken DCTN1 (426238), domestic cat DCTN1 (101084533), dog DCTN1 (483106) ...More
UniProtKB ID:
Gene ID:
- Human(1639) Summary: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
- Mouse(13191) dynactin 1
- Rat(29167) dynactin 1
- sheep(101116037) dynactin 1
- Domestic Rabbit(100346609) dynactin 1
- domestic guinea pig(100714202) dynactin 1
- naked mole-rat(101703706) dynactin 1
- chicken(426238) dynactin 1
- domestic cat(101084533) dynactin 1
- dog(483106) dynactin 1
- cow(511045) dynactin 1
- Horse(100053938) dynactin 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-DCTN1 antibody produced in mouse, clone 1E12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Monoclonal Anti-DCTN1 antibody produced in mouse, clone 2E4-1C2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-DCTN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-DCTN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-Dctn1 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
esiRNA
Product Number
Description
Species