DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Synonyms:
DOC-2, DOC2
Species:
Human DAB2 (1601), Mouse Dab2 (13132), Rat Dab2 (79128), Zebrafish dab2 (404040), domestic cat DAB2 (101096539), cow DAB2 (509221), Horse DAB2 (100066655), dog DAB2 (479353), chicken DAB2 (427449), sheep DAB2 (101104604) ...More
UniProtKB ID:
Gene ID:
- Human(1601) Summary: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- Mouse(13132) disabled 2, mitogen-responsive phosphoprotein
- Rat(79128) disabled 2, mitogen-responsive phosphoprotein
- Zebrafish(404040) disabled homolog 2 (Drosophila)
- domestic cat(101096539) disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
- cow(509221) disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
- Horse(100066655) disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
- dog(479353) disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
- chicken(427449) disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
- sheep(101104604) disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
- naked mole-rat(101725399) Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
- domestic guinea pig(100734816) Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-DAB2, (C-terminal) antibody produced in mouse, clone 1C8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-DAB2 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-DAB2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Monoclonal Anti-DAB2 antibody produced in mouse, clone 3D6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-DAB2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, canine, human, rat
Application
ELISA
western blot
western blot
esiRNA
Product Number
Description
Species