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MilliporeSigma

CTSL

cathepsin L

Synonyms:
CATL, CTSL1, MEP
Species:
Human CTSL (1514), Mouse Ctsl (13039)
UniProtKB ID:
Gene ID:
  • Human(1514) Summary: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
  • Mouse(13039) cathepsin L

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ELISA

Product Number
Description
Species
RAB0635
Human CTSL / Cathepsin L1 ELISA Kit, ,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
SAB4300959
Anti-CTSL antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
HPA070413
Anti-CTSL antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
western blot
SAB5702994
Anti-Cathepsin L/V/K/H Antibody, clone 2Q10F10, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot
C2970
Monoclonal Anti-Cathepsin L antibody produced in mouse, clone 33/2, ascites fluid,
Species Reactivity
human, mink, mouse, rat
Application
ELISA
immunohistochemistry
microarray
western blot

Proteins

Product Number
Description
Species
219402
Cathepsin L, Human Liver, Cathepsin L, Human Liver, CAS 60616-82-2, is a native, the most potent of all the lysosomal proteinases. Plays a major role in the proteolysis of both cellular and endocytosed macromolecules.,
Species
human
SRP0291
Cathepsin L Active human, recombinant, expressed in FreeStyle™ 293-F cells, ≥90% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
EHU106791
MISSION® esiRNA, targeting human CTSL,
Species
human