CRYBB3
crystallin, beta B3
Synonyms:
CATCN2, CRYB3, CTRCT22
Species:
Human CRYBB3 (1417), Mouse Crybb3 (12962), Rat Crybb3 (64349), Zebrafish crybb3 (553184), chicken CRYBB3 (396108), domestic cat CRYBB3 (101082953), cow CRYBB3 (282206), dog CRYBB3 (790954), naked mole-rat Crybb3 (101709702), domestic guinea pig Crybb3 (100306963)
UniProtKB ID:
Gene ID:
- Human(1417) Summary: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2. Mutations in this gene result in cataract congenital nuclear autosomal recessive type 2. [provided by RefSeq, Feb 2013]
- Mouse(12962) crystallin, beta B3
- Rat(64349) crystallin, beta B3
- Zebrafish(553184) crystallin, beta B3
- chicken(396108) crystallin, beta B3
- domestic cat(101082953) crystallin, beta B3
- cow(282206) crystallin, beta B3
- dog(790954) crystallin, beta B3
- naked mole-rat(101709702) crystallin, beta B3
- domestic guinea pig(100306963) crystallin, beta B3
- sheep(780513) crystallin, beta B3
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.