BBC3
BCL2 binding component 3
Synonyms:
JFY-1, JFY1, PUMA
Species:
Human BBC3 (27113), Mouse Bbc3 (170770), Rat Bbc3 (317673), naked mole-rat Bbc3 (101714844), domestic guinea pig Bbc3 (101788977), Zebrafish bbc3 (751763), cow BBC3 (782359), dog BBC3 (612153)
UniProtKB ID:
Gene ID:
- Human(27113) Summary: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
- Mouse(170770) BCL2 binding component 3
- Rat(317673) Bcl-2 binding component 3
- naked mole-rat(101714844) BCL2 binding component 3
- domestic guinea pig(101788977) BCL2 binding component 3
- Zebrafish(751763) BCL2 binding component 3
- cow(782359) BCL2 binding component 3
- dog(612153) BCL2 binding component 3
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PUMA/bbc3, N-Terminal antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
microarray
western blot
western blot
Anti-PUMA (ab2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-PUMA antibody produced in mouse, clone 10C5G1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, rat
Application
ELISA
western blot
western blot
Monoclonal Anti-PUMA antibody produced in mouse, clone 2A9G5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot